Welcome to Session 1: Coronavirus Emergence & Trajectory

This session will explore the origins of COVID-19. We will discuss the epidemiology and pathogenesis of COVID-19 and explain why it is called a novel coronavirus and why this is concerning. We will then delve into the trajectory of COVID-19 both on an international and local level, while examining the large outbreak in Seattle.

Learning Objectives

After completing this module, you will be able to:

Discuss the epidemiology and pathogenesis of COVID-19
Explain why COVID-19 became a pandemic and how it spread around the world and in Seattle

Guest Lecturers

Judy Wasserheit, MD, MPH
Chair, Global Health
Professor, Global Health
Professor, Medicine - Allergy and Infectious Disease
Adjunct Professor, Epidemiology

Dr. Wasserheit has worked extensively at the interface of sexually transmitted infections (STI) and HIV clinical-epidemiological research, programs and policy in the U.S. and globally. Currently Professor and Chair, of Global Health at the University of Washington, as well as Professor of Medicine and Epidemiology, she was the Founding Chief of the U.S. NIH’s STD Research Branch; Director of the U.S. CDC’s STD/HIV Prevention Program, and Director of the HIV Vaccine Trials Network. She has worked in Bangladesh, Colombia, Egypt, Indonesia, Kenya, Thailand and Zambia. Her development of the concept of epidemiological synergy between HIV infection and other sexually transmitted infections has had a major influence on HIV prevention policy and programs worldwide.

Peter Rabinowitz, MD, MPH
Professor, Global Health
Professor, Env. and Occ. Health Sciences
Professor, Family Medicine
Adjunct Professor, Epidemiology
Adjunct Professor, Medicine - Allergy and Infectious Disease

Dr. Rabinowitz is Professor in the Departments of Environmental and Occupational Health Sciences, Family Medicine, Global Health, Epidemiology, and Medicine (Infectious Disease), University of Washington. He received his BA from Amherst College, his MD from the University of Washington, and completed a Family Medicine residency through UCSF, and fellowships in General Preventive Medicine and Occupational and Environmental Medicine at Yale. He directs the UW Center for One Health Research that serves as an incubator and organizer of research, training, and clinical activities related to the human-animal-ecosystem interface. Focus areas of Center research include microbiome sharing between humans, animals, and environments, antimicrobial resistance, and diagnosis, treatment, and prevention of zoonotic diseases.

Jason Beste ,MD, MPH

Clinical Instructor, Department of Medicine, Division of Allergy & Infectious Diseases

Co-Director, UW Global & Rural Health Fellowship

Director, Global Health Pathway, UW School of Medicine

Director, MD-MPH Pathway, UW School of Medicine

Dr. Beste is an infectious disease and internal medicine specialist at the University of Washington School of Medicine. Dr. Beste's research interests include health systems strengthening work in conflict and post-conflict countries. He also works at UW's International Training and Education Center for Health (I-TECH) as an International Clinical Advisor where he specializes in global health HIV projects. In addition to providing clinical care at UWMC-Montlake and Harborview Medical Center, Dr. Beste is involved with medical and graduate education where he directs the UW School of Medicine's MD-MPH program, Global Health Pathway, Global Health Immersion Program and co-directs the UW Global and Rural Health Fellowship Program.

Recorded Session (1 hour)

If you missed the live session, watch the recording here.

Slides: Judy Wasserheit

Slides: Peter Rabinowitz

Download MP4 113MB

Readings

These readings reinforce the lecture and may clarify any concepts from the lecture you might not understand.

Zhu, N. et al. A Novel Coronavirus from Patients with Pneumonia in China, 2019. New England Journal of Medicine. Feb 20, 2020.
Wu, F. et al. A new coronavirus associated with human respiratory disease in China . Nature. V597. 2020.
Holshue, M. et al. First Case of 2019 Novel Coronavirus in the United States . New England Journal of Medicine. Mar 5, 2020.
WHO: Coronavirus Disease (COVID-19) Pandemic. 2020
Morens, D. et al. Escaping Pandora’s Box — Another Novel Coronavirus. New England Journal of Medicine. 2020.
Kimball, A. et al. Asymptomatic and Presymptomatic SARS-CoV-2 Infections in
Residents of a Long-Term Care Skilled Nursing Facility — King County, Washington, March 2020. CDC MMWR. March 27, 2020.
Anderson, R.M. et al. How will country-based mitigation measures influence the course of the COVID-19 epidemic? The Lancet Vol 395 March 21, 2020.
Jin, Y. et al. Virology, Epidemiology, Pathogenesis, and Control of COVID-19 . Viruses. 12, 372. 2020.
Roxby, A.C., et al. Detection of SARS-CoV-2 Among Residents and Staff Members of an Independent and Assisted Living Community for Older Adults — Seattle, Washington, 2020. CDC MMWR. April 3, 2020
Gates, B. Responding to Covid-19 — A Once-in-a-Century Pandemic? New England Journal of Medicine . Feb 28, 2020.
Ceraolo, C. and Giorgi, F.M. Genomic variance of the 2019‐nCoV coronavirus . Journal of Medical Virology. 2020;92:522–528.
Huang, C. et al. Clinical features of patients infected with 2019 novel
coronavirus in Wuhan, China. The Lancet. Vol 395. February 15, 2020.